威斯尼斯人老品牌 【2021版】

赵小凡
作者:   时间:2017-12-12   点击数:

赵小凡 教授

二级教授、山东大学特聘教授、享受国务院特殊津贴

E-Mailxfzhao@sdu.edu.cn

教育背景

博士: 1996-1997 南京农业大学 昆虫生理

硕士: 1982-1984 山东大学 动物学

本科: 1978-1981 西南师范大学 生物学

工作经历

1984-1987 山东大学 讲师

1987-1994 山东大学 副教授

1994-1999 山东大学 教授

2000-至今 山东大学 博导

科研经历及成果:

从事昆虫生理生化与分子生物学研究,重点研究昆虫发育过程中蜕皮与变态的功能基因和分子调控机理。承担本科生和研究生教学工作。1981年毕业于西南师范大学, 1984年获山东大学硕士学位, 1990-1991年赴日本从事家蚕半胱氨酸蛋白酶研究,1997年获南京农业大学博士学位。1998-2000年获德国政府学术交流会(DAAD生物科学特别项目博士后奖学金赴德国从事烟草天蛾V-ATP酶研究;2001-2002年在日本九州工业大学从事DNA和蛋白质测序、基因重组蛋白包涵体复性和纯化、毕赤酵母表达外源蛋白等研究;2003年获德国政府德意志联合研究会(DFG)资助赴德国从事基因重组病毒杀虫剂构建和蛋白酶、HHR3在昆虫细胞中的表达等研究。2005年赴日本从事蛋白质组学研究。2006年赴美国密苏里大学进行短期科研工作。先后承担国家自然科学基金重点项目、重大国际合作项目和面上项目;参加国家“973”“863”项目;以及承担山东省自然科学基金重点项目等科研项目10余项。主要学术成果包括:阐明了G蛋白偶联受体(GPCR)是昆虫蜕皮激素(20E)的膜受体, 蜕皮激素通过GPCR介导的细胞膜信号途径调控EcR/USP介导的核受体信号途径,蜕皮激素通过GPCR引起快速的钙离子流入以促进细胞凋亡和昆虫变态, 蜕皮激素上调磷脂酰肌醇3磷酸磷酸酶(PTEN)的表达从而对抗胰岛素活性,蜕皮激素通过蛋白激酶调控蜕皮激素核受体磷酸化从而促进昆虫化蛹。在系列研究的基础上提出了昆虫蜕皮激素的细胞膜信号转导途径的模型,开辟了昆虫蜕皮激素信号途径研究的新方向,为研发控制害虫的生长调节剂绿色农药提供了理论依据和靶标基因。研究成果发表在PNASPLoS Genetics, DevelopmentEndocrinology, JBCCell Commun SignalInsect Biochem Mol Biol等刊物上。撰写了十一五国家级规划教材《发育生物学》第20章《昆虫蜕皮与变态》,张红卫主编,高等教育出版社,2018年第4版。受法国James Devillers 教授邀请撰写了专著《Juvenile hormones and Juvenoids》第五章《保幼激素及类似物在基因转录中的作用》,Taylor & Francis出版社,2013

科研方向

以重大农业害虫棉铃虫为材料,用分子生物学方法研究昆虫蜕皮与变态的分子机理,包括蜕皮激素信号转导途径、保幼激素信号途径、胰岛素信号途径、及这些途径之间的互作调控基因的表达、组织重建的分子机理。

在研课题:

1. G-蛋白偶联受体在蜕皮激素拮抗胰岛素并促进化蛹中的作用及分子机制。国家自然科学基金,重点: 201801 012022 1231

已完成课题:

18. 钙信号途径在昆虫变态发育中的功能及激素调控。国家自然科学基金:201601月至 2019 12

17. 昆虫蜕皮激素的细胞膜受体及膜信号转导途径研究,国家自然科学基金重点。2013.1-2017.12

16. 害虫暴发成灾的遗传与行为机理,国家重大基础研究项目9732012.1-2016.12

15. 昆虫血细胞在变态中的功能和作用机理, 国家自然科学基金。2010.1-2012.12. 项目负责人。

14. 昆虫蜕皮激素信号转导途径研究, 国家自然科学基金重大国际合作项目, 2008.1-2011.12月。项目负责人。

13. 重大农业害虫猖獗危害的机制及可持续控制的基础研究——害虫生长发育与生殖调控的分子机制。国家重大基础研究项目(973)。2006.1-2010.12。参加。

12. 家蚕重要经济性状功能基因克隆,国家高技术研究发展计划(863计划)2006. 1-2010.12 参加。

11.棉铃虫皮层溶离中蛋白酶表达及调控研究,国家自然科学基金, 2007.1-2009.12。项目负责人。

10. 棉铃虫蜕皮级联反应功能基因表达研究, 国家自然科学基金重点项目,2004.1-2007.12。项目负责人。

9. 基因重组病毒杀虫剂研究,山东省自然科学基金重点项目,2004.1-2006.12. 项目负责人。

8. 重组病毒杀虫剂的研制, 863,国家科技部, 2001-2004. 项目负责人。

7. 棉铃虫蜕皮调节转录因子基因克隆和表达载体构建,国家自然科学基金,2001.1-2003.1. 项目负责人。

6. 棉铃虫卵蛋白酶基因克隆及功能表达, 国家自然科学基金, 1999.1-2001.12. 项目负责人。

5. RH-化合物对棉铃虫的防治效果研究, 山东省科委国际合作基金, 1998.1-2000.12. 项目负责人。

4. 蜕皮激素类似物合成及对棉铃虫的防治研究, 山东省科委优秀年轻教师奖励基金,1999.1-2000.12. 项目负责人。

3. 棉铃虫卵内蛋白酶纯化, 国家自然科学基金主任基金, 1998.1-12. 项目负责人。

2. 鳞翅目昆虫卵内蛋白酶纯化性质与cDNA克隆. 国家教育部优秀年轻教师基金, 1996.1-1998.12. 项目负责人。

1. 蓖麻蚕卵黄蛋白质降解酶研究,国家教育部留学回国人员基金,1992.1-1994.12. 项目负责人。

代表性论文:*为通讯作者

103. Yu-Qin Di, Yu-Meng Zhao, Ke-Yan Jin, Xiao-Fan Zhao*. 2021, Subunit P60 of phosphatidylinositol 3-kinase promotes cell proliferation or apoptosis depending on its phosphorylation status. PLoS Genetics. Apr 26;17(4):e1009514.

102. Xin-Le Kang, Yan-Xue Li, Yan-Li Li, Jin-Xing Wang and Xiao-Fan Zhao*. 2021. The homotetramerization of a GPCR transmits the 20-hydroxyecdysone signal and increases its entry into cells for insect metamorphosis. Development. Mar 10;148(5):dev196667.

101. Yan-Li Li, You-Xiang Yao, Yu-Meng Zhao, Yu-Qin Di, and Xiao-Fan Zhao*. 2021. The steroid hormone 20-hydroxyecdysone counteracts insulin signaling via insulin receptor dephosphorylation. The Journal of Biological Chemistry. Jan. 296:100318.

100. Yan-Li Li, Yan-Xue Li, Xiao-Pei Wang, Xin-Le Kang, Ke-Qin Guo, Du-Juan Dong, Jin-Xing Wang, Xiao-Fan Zhao*. 2021. Identification and functional analysis of G protein-coupled receptors in 20-hydroxyecdysone signaling from the Helicoverpa armigera Genome. Frontiers in Cell and Developmental Biology. Oct 26;9:753787.

99. Yan-Xue Li, Di Wang, Wen-Li Zhao, Jun-Ying Zhang, Xin-Le Kang, Yan-Li Li, Xiao-Fan Zhao*. 2021. Juvenile hormone induces methoprene-tolerant 1 phosphorylation to increase interaction with Taiman in Helicoverpa armigera. Insect Biochemistry and Molecular Biology. Mar; 130:103519.

98. Yu-Qin Di , Xiao-Lin Han, Xin-Le Kang , Di Wang , Cai-Hua Chen , Jin-Xing Wang , and Xiao-Fan Zhao*. 2021. Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis. Autophagy. May;17(5):1170-1192.

97. Xiao-Fan Zhao. 2020. G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone. Cell Communication and Signaling. Sep 9;18(1):146.

96.Xiao-Fan Zhao. 2020. Progress in understanding hormonal regulation during the post-embryonic development of Helicoverpa armigera. Journal of Integrative Agriculture. 19(6): 1417–1428.

95. Xin-Le Kang, Jun-Ying Zhang, Di Wang, Yu-Meng Zhao, Xiao-Lin Han, Jin-Xing Wang, Xiao-Fan Zhao*. 2019. The steroid hormone 20-hydroxyecdysone binds to dopamine receptor to repress lepidopteran insect feeding and promote pupation. PLoS Genetics. Aug 14;15(8):e1008331.

94. Cai-Huan Chen, Yu-Qin Di, Qin-Yong Shen, Jin-Xing Wang, Xiao-Fan Zhao*. 2019, The steroid hormone 20-hydroxyecdysone induces phosphorylation and aggregation of stromal interacting molecule 1 for store-operated calcium entry. The journal of Biological Chemistry. Aug 14.

93. Jing Pan1, Yu-Qin Di1, Yong-Bo Li, Cai-Huan Chen, Jin-Xing Wang, Xiao-Fan Zhao*. Insulin and 20-hydroxyecdysone oppose each other in the regulation of phosphoinositide-dependent kinase-1 expression during insect pupation. The journal of Biological Chemistry. 2018Nov 30;293(48):18613-18623.

92. Yong-Bo Li, Ting Yang, Jin-Xing Wang, Xiao-Fan Zhao*. The steroid hormone 20-hydroxyecdysone regulates the conjugation of autophagy-related proteins 12 and 5 in a concentration and time-dependent manner to promote insect midgut programmed cell death. Front Endocrinol (Lausanne). 2018 Feb 7;9:28.

91. Yong-Bo Li, Xu-Yang Pei, Di Wang, Cai-Hua Chen, Mei-Juan Cai, Jin-Xing Wang, Xiao-Fan Zhao*. 2017, The steroid hormone 20-hydroxyecdysone upregulates calcium release-activated calcium channel modulator 1 expression to induce apoptosis in the midgut of Helicoverpa armigera. Cell Calcium, Oct. 19. 68: 24–33.

90.Cai-Hua Chen, Jing Pan, Yu-Qin Di, Wen Liu, Li Hou, Jin-Xing Wang, and Xiao-Fan Zhao*. 2017, Protein kinase C delta phosphorylates ecdysone receptor B1 to promote gene expression and apoptosis under 20-hydroxyecdysone regulation.Proc Natl Acad Sci U S A., 2017Aug 22;114(34):E7121-E7130.

89. Di Wang, Xiang-Ru Li, Du-Juan Dong, Hua Huang, Jin-Xing Wang, Xiao-Fan Zhao*. 2016, Oct 7. The steroid hormone 20-hydroxyecdysone promotes the cytoplasmic localization of Yorkie to suppress cell proliferation and induce apoptosis. The journal of Biological Chemistry. 291(41):21761-21770.

88. Yong-Bo Li, Xiang-Ru Li, Ting Yang, Jin-Xing Wang, Xiao-Fan Zhao*. 2016, Oct. 21. The steroid hormone 20-hydroxyecdysone promotes switching from autophagy to apoptosis by increasing intracellular calcium levels. Insect Biochemistry and Molecular Biology 79 :73-86.

87. Wen-Li Zhao, Di Wang, Chun-Yan Liu & Xiao-Fan Zhao*. 2016, Jul 14. G-protein-coupled receptor kinase2 terminates G-protein-coupled receptor function in steroid hormone 20-hydroxyecdysone signaling. Scientific Reports,|6:29205.

86. Di Wang, Xu-Yang Pei, Wen-Li Zhao, Xiao-Fan Zhao*. 2016, May 7. Steroid hormone 20-hydroxyecdysone promotes higher calciummobilization to induce apoptosis. Cell Calcium, 60:1-12.

85. Yu-Pu Jing, Di Wang, Xiao-Lin Han, Du-Juan Dong, Jin-Xing Wang, and Xiao-Fan Zhao*. 2016, June 10. The steroid hormone 20-hydroxyecdysone enhances gene transcription through the cAMP response element-binding protein (CREB) signaling pathway. The journal of Biological Chemistry. 291: 12771–12785.

84. Cai MJ, Zhao WL, Jing YP, Song Q, Zhang XQ, Wang JX, Zhao XF*. 2016, 20-hydroxyecdysone activates Forkhead box O to promote proteolysis during Helicoverpa armigera molting. Development. Feb 18. 143: 1005-1015.

83. Chun-Yan Liu, Wen-Li Zhao, Jin-Xing Wang &Xiao-Fan Zhao*. 2015, Cyclin-dependent kinase regulatory subunit 1 promotes cell proliferation by insulin regulation. Cell Cycle, 14:19, 3045—3057.

82.Zhang XQ, Li XR, Ren J, Li YB1, Cai MJ, Wang JX, Zhao XF*. 2015, β-Arrestin1 interacts with G protein-coupled receptor to desensitize signaling ofthe steroid hormone 20-hydroxyecdysone in the lepidopteran insect Helicoverpa armigera. Cell Signal. Apr; 27(4):878-86.

81.Wang D, Zhao WL, Cai MJ, Wang JX, Zhao XF*. 2015, G-protein-coupled receptor controls steroid hormone signaling in cell membrane. Sci Rep. Mar 2;5:8675. doi: 10.1038/srep08675.

80. Dong DJ, Jing YP, Liu W, Wang JX, Zhao XF*. 2015, The steroid hormone 20-hydroxyecdysone up-regulates Ste-20 family serine/threonine kinase Hippo to induce programmed cell death. J Biol Chem. Oct 9; 290(41):24738-46.

79. Lu Li, Liping Shen, Xiaoqian Zhang, Lingling Shui, Benhui Sui, Xiaoli Zhang,Xiaofan Zhao*, Wenrui Jin*, 2015 Multiplexed optical coding nanobeads and their application in single-molecule counting analysis for multiple gene expression analysis. Anal Chim Acta 886, 123-132;

78. Yu-Pu Jing, Wen Liu, Jin-Xing Wang, andXiao-Fan Zhao* 2015, The steroid hormone 20-hydroxyecdysone via nongenomic pathway activates Ca2+/calmodulin-dependent protein kinase II to regulate gene expression. J Biol Chem 290, 8469-8481.

77. Cai Mei-Juan, Li Xiang-Rr, Pei Xu-Yang, Liu Wen, Wang Jing-Xing andZhao Xiao-Fan*. 2014, Heat shock protein 90 maintains the stability and function of transcription factor Broad Z7 by interacting with its Broad-Complex-Tramtrack-Bric-a-brac domain. Insect Molecular Biology, July, 23(6), 720–732.

76. Cai Mei-Juan, Liu Wen, Pei Xu-Yang, Li Xiang-Ru, He Hong-Juan, Wang Jin-Xing, andZhao Xiao-Fan*. 2014, Juvenile hormone prevents 20-hydroxyecdysone-induced metamorphosis by regulating the phosphorylation of a newly identified Broad Protein. The journal of Biological Chemistry. Sep 19; 289(38):26630–26641.

75. Ren Jing, Li Xiang-Ru, Liu Peng-Cheng, Cai Mei-Juan, Liu Wen, Wang Jin-Xing,Zhao Xiao-Fan*, 2014, G-protein aq participates in the steroid hormone 20-hydroxyecdysone nongenomic signal transduction. Journal of Steroid Biochemistry & Molecular Biology. Aug 12; 144:313–323.

74. Zhao Wen-Li, Liu Chun-Yan, Liu Wen, Wang Di, Wang Jin-Xing,Zhao Xiao-Fan*. 2014, Methoprene-tolerant 1 regulates gene transcription to maintain insect larval status. Journal of Molecular Endocrinology. Aug; 53(1):93-104.

73. Liu Wen, Cai Mei-Juan, Zheng Chuan-Chuan, Wang Jin-Xing,Zhao Xiao-Fan*, 2014, Phospholipase C gamma 1 connects the cell membrane pathway to the nuclear receptor pathway in insect steroid hormone signaling. The Journal of Biological Chemistry. May 9; 289(19):13026-13041.

72. Liu Wen, Cai Mei-Juan, Wang Jin-Xing,Zhao Xiao-Fan*, 2014, In a nongenomic action, steroid hormone 20-hydroxyecdysone induces phosphorylation of cyclin-dependent kinase 10 to promote gene transcription. Endocrinology. May; 155(5):1738-1750.

71. Cai Mei-Juan, Dong Du-Juan, Wang Yu, Liu Peng-Cheng, Liu Wen, Wang Jin-Xing and Zhao Xiao-Fan *, 2014, G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membrane. Cell Communication & Signaling. Feb. 12: 9.

70. Dong Du-Juan, Liu Wen, Cai Mei-Juan, Wang Jin-Xing,Zhao Xiao-Fan*, 2013, Steroid hormone 20-hydroxyecdysone regulation of the very-high-density lipoprotein (VHDL) receptor phosphorylation for VHDL uptake. Insect Biochemistry and Molecular Biology. Feb. 3, 43: 328-335.

69. Liu Wen, Zhang Feng-Xia, Cai Mei-Juan, Zhao Wen-Li, Li Xiang-Ru, Wang Jin-Xing,Zhao Xiao-Fan*, 2013,The hormone-dependent function of Hsp90 in the crosstalk between 20-hydroxyecdysone and juvenile hormone signaling pathways in insects is determined by differential phosphorylation and protein interactions. Biochimica et Biophysica Acta. Jun 29, 1830: 5184–5192.

68. Liu Chun-Yan, Liu Wen, Zhao Wen-Li, Wang Jin-Xing,Zhao Xiao-Fan*, 2013, Upregulation of the expression of prodeath serine/threonine protein kinase for programmed cell death by steroid hormone 20-hydroxyecdysone. Apoptosis. Dec 1, 18:171-187.

67. Chen Ru-Ping, Liu Chun-Yan, Shao Hong-Lian, Zheng Wei-Wei, Wang Jin-Xing,Zhao Xiao-Fan*, 2012, Adenylate kinase 2 (AK2) promotes cell proliferation in insect development. BMC Molecular Biology. Sep 28, 13(1):31.

66. Cai Mei-Juan, Liu Wen, He Hong-Juan, Wang Jin-Xing,Zhao Xiao-Fan*, 2012, Mod(mdg4) participates in hormonally regulated midgut programmed cell death during metamorphosis. Apoptosis. Sep, 17:1327–1339.

65. Hou Li, Cai Mei-Juan, Liu Wen, Song Qian,Zhao Xiao-Fan*, 2012, Small GTPase Rab4b participates in the gene transcription of 20-hydroxyecdysone and insulin pathways to regulate glycogen level and metamorphosis. Developmental Biology. May 13. 371: 13–22.

64. Zhai Xiang andZhao Xiao-Fan*, 2012, Participation of haemocytes in fat body degradation via cathepsin L expression. Insect Molecular Biology. Aug. 21(5):521–534.

63. Wang Chuan-Xu, Zheng Wei-Wei,Liu Peng-Cheng, Wang Jin-Xing,Zhao Xiao-Fan*, 2012, The steroid hormone 20-hydroxyecdysone upregulated the protein phosphatase 6 for the programmed cell death in the insect midgut. Amino Acids. Aug; 43(2):963-71.

62. Dong Du-Juan, Liu Peng-Cheng, Wang Jin-Xing,Zhao Xiao-Fan*, 2012, The knockdown of Ha-GRIM-19 by RNA interference induced programmed cell death. Amino Acids. Apr .42(4):1297-307.

61. He Hong-Juan, Hou Li, Wang Jin-Xing,Zhao Xiao-Fan*, 2012, The apoptosis inhibitor survivin prevents insect midgut from cell death during postembryonic development. Molecular Biology Report. Feb. 39(2):1691-9.

60. Zhang Feng-Xia, Shao Hong-Lian, Wang Jin-Xing,Zhao Xiao-Fan*, 2011, β-thymosin is upregulated by the steroid hormone 20-hydroxyecdysone and microorganisms. Insect Molecular Biology. Aug. 20, 519–527.

59. Wang Gang, Liu Peng-Cheng, Wang Jin-Xing,Zhao Xiao-Fan*, 2011, A BTB domain-containing gene is upregulated by immune challenge. Archives of Insect Biochemistry and Physiology. Jun; 77:58-71.

58. Liu Peng-Cheng, Wang Jin-Xing, Song Qi-Sheng,Zhao Xiao-Fan*,2011, The participation of calponin in the crosstalk between 20-Hydroxyecdysone and juvenile hormone signaling pathways by phosphorylation variation. PLoS ONE. May 19. 6: e19776.

57. Hou Li, Wang Jin-Xing,Zhao Xiao-Fan*,2011, Rab32 and the remodeling of the imaginal midgut in Helicoverpa armigera. Amino Acids. Mar 40:953–961.

56. Yang Xiao-Hui, Liu Peng-Cheng, Zheng Wei-Wei, Wang Jin-Xing,Zhao Xiao-Fan*, 2011, The juvenile hormone analogue methoprene up-regulates the Ha-RNA-binding protein. Molecular and Cellular Endocrinology. 333: Feb 172–180.

55. Wang Jia-Lin, Wang Li-fu, Wang Jin-Xing,Zhao Xiao-Fan*, 2010, The expression patterns of a eukaryotic initiation factor 3 subunit h in the silk glands in Bombyx mori.Archives of Insect Biochemistry and Physiology. Sep; 75:1-12.

54. Wang Qian, Liu Yang, He Hong Juan,Zhao Xiao-Fan*,Jin-Xing Wang*, 2010, Immune response of Helicoverpa armigera to different kinds of pathogens. BMC Immunology. Mar 11:9.

53. He Hong-Juan, Wang Qian, Zheng Wei-Wei, Wang Jin-Xing, Song Qi-Sheng,Zhao Xiao-Fan*, 2010, Function of Nuclear Transport Factor 2 and Ran in the 20E signal transduction pathway in the Cotton Bollworm, Helicoverpa armigera. BMC Cell Biology. Jan 11:1.

52. Wang Li-Fu, Chai Lian-Qin, He Hong-Juan, Wang Qian, Wang Jin-Xing,Zhao Xiao-Fan*, 2010, The cathepsin L-like proteinase is involved in molting and metamorphosis in Helicoverpa armigera. Feb; Insect Molecular Biology. 19:99-111.

51. Zheng Wei-Wei, Yang Dan-Tong, Wang Jin-Xing, Song Qi-Sheng, Gilbert Lawrence I.,Zhao Xiao-Fan*, 2010, Hsc70 binds to ultraspiracle resulting in the upregulation of 20-hydroxyecdsone-responsive genes in Helicoverpa armigera. Molecular and Cellular Endocrinology. Feb ;315: 282-291.

50. Fu Qiang, Liu Peng-Cheng, Wang Jin-Xing, Song Qi-Sheng,Zhao Xiao-Fan*, 2009, Proteomic identification of differentially expressed and phosphorylated proteins in epidermis involved in larval-pupal metamorphosis of Helicoverpa armigera. BMC Genomics. Dec 10:600.

49. Liu Yang, Sui Yi-Peng, Wang Jin-Xing andZhao Xiao-Fan*, 2009, Characterization of the trypsin-like protease (ha-tlp2) constitutively expressed in the integument of the cotton bollworm, Helicoverpa armigera. Archives of Insect Biochemistry and Physiology. Oct 72:74-87.

48. Sui Yi-Peng, Wang Jin-Xing andZhao Xiao-Fan*, 2009, The impacts of classical insect hormones on the expression profiles of a new digestive trypsin-like protease (TLP) from the cotton bollworm, Helicoverpa armigera. Insect Molecular Biology. Aug; 18: 443-452.

47. Sui Yi-Peng, Liu Xiao-Bin, Chai Lian-Qin, Wang Jin-Xing,Zhao Xiao-Fan*, 2009, Characterization and influences of classical insect hormones on the expression profiles of a molting carboxypeptidase A from the cotton bollworm (Helicoverpa armigera). Insect Molecular Biology. Jun; 18: 353–363.

46. Dong Du-Juan, Wang Jin-Xing,Zhao Xiao-Fan*. 2009, A eukaryotic initiation factor 5C is upregulated during metamorphosis in the cotton bollworm, Helicoverpa armigera. BMC Developmental Biology. Mar 8; 9:19.

45. Wang Jia-Lin, Zhang Ya-Ping, Gu Yin-Yu, Wang Jin-Xing andZhao Xiao-Fan*, 2009, Function of a TGF-inducible nuclear protein in the silk gland in Bombyx mori. Insect Molecular Biology. Apr; 18: 243–251.

44. Tian Yuan-Yuan, Liu Yang,Zhao Xiao-Fan*, Wang Jin-Xing*, 2009, Characterization of a C-type lectin from the cotton bollworm, Helicoverpa armigera. Developmental and Comparative Immunology. Jun; 33:772–779.

43. Shao Hong-Lian, Zheng Wei-Wei, Liu Peng-Cheng, Wang Qian, Wang Jin-Xing,Zhao Xiao-Fan*, 2008, Establishment of a New Cell Line from Lepidopteran Epidermis and Hormonal Regulation on the Genes. PLoS ONE Sep 3; 3: e3127.

42. Sui Yi-Peng, Wang Jin-Xing andZhao Xiao-Fan*,2008, Effects of classical insect hormones on the expression profiles of a lipase gene from the cotton bollworm (Helicoverpa armigera). Insect Molecular Biology. Sep;17: 523 – 529.

41. Shao Hong-Lian, Dong Du-Juan, Hu Jin-Dong, Wang Jin-Xin,Zhao Xiao-Fan*,2008, Construction of the recombinant baculovirus AcMNPV with cathepsin B-like proteinase and its insecticidal activity against Helicoverpa armigera. Pesticide Biochemistry and Physiology. May; 91:141-161.

40. Wang Jia-Lin, Wang Jin-XingZhao Xiao-Fan*, 2008, Molecular Cloning and Expression Profiles of the Acyl-CoA-Binding Protein Gene From the Cotton Bollworm Helicoverpa armigera. Archives of Insect Biochemistry and Physiology. Jun; 68:79–88.

39Chai Lian-Qin, Tian Yuan-Yuan, Yang Dan-Tong, Wang Jin-Xing,Zhao Xiao-Fan*, 2008, Molecular cloning and characterization of a C-type lectin from the cotton bollworm, Helicoverpa armigera. Developmental & Comparative Immunology. 32:71-83. May 24.

38Yang Dan-Tong, Chai Lian-Qin, Wang Jin-Xing,Zhao Xiao-Fan*, 2008, Molecular cloning and characterization of Hearm caspase-1 from Helicoverpa armigera. Molecular Biology Report. Sep; 35:405-12.

37. Yang Xiao-Mei, Hou Li-Jing, Wang Jin-Xing,Zhao Xiao-Fan*, 2007, Expression and Function of Cathepsin B-Like Proteinase in Larval Hemocytes of Helicorverpa armigera during Metamorphosis. Archives of Insect Biochemistry and Physiology. Apr; 64:164–174.

36. Hu Jindong, Shao Honglian, Zhang Yubao, Fu Qiang, Sun ChenWang Jinxing,Zhao Xiaofan*2007Construction of HaSNPV with Helicoverpa hormone receptor 3. High Technology Letters, May; 3327-331.

35. Shao Hong-LianDong Du-JuanHu Jin-DongZhang Xin-ChangZhang Yu-BaoFu QiangSun ChenWang Jin-XinZhao Xiao-Fan*,2007, Reconstruction of AcMNPV with Helicoverpa hormone receptor 3 and its effect on the Helicoverpa larvae. Biocontrol Science and Technology. May; 17: 95-104.

34. Dong Du-Juan1, He Hong-Juan1, Chai Lian-Qin1, Jiang Xiao-Juan, Wang Jin-Xing,Zhao Xiao-Fan*, 2007, Identification of genes differentially expressed during larval molting and metamorphosis of Helicoverpa armigera. BMC Developmental Biology. Jun ; 7:73.

33Wang Jia-Lin, Jiang Xiao-Juan, Wang Qian, Hou Li–Jing, Xu Da-Wei, Wang Jin-Xing,Zhao Xiao-Fan*, 2007, Identification and expression profile of a putative basement membrane protein gene in the midgut of Helicoverpa armigera. BMC Developmental Biology. Jun ;7:76.

32. Zhang Xin-Chang, Shao Hong-Lian, Wang Jin-Xing,Zhao Xiao-Fan*, 2006, Purification of an inhibitor of Helicoverpa cathepsin B-like proteinase from sunflower seed. Journal of Enzyme Inhibition and Medicinal Chemistry. Aug; 21: 433–439.

31. Yang Xiao-Mei, Hou Li-Jing, Dong Du-Juan, Shao Hong-Lian, Wang Jin-Xing,Zhao Xiao-Fan*, 2006, Cathepsin B-Like Proteinase Is Involved in the Decomposition of the Adult Fat Body of Helicoverpa armigera. Archives of Insect Biochemistry and Physiology. May; 62:1-10.

30.Zhao Xiao-Fan*, He Hong-Juan, Dong Du-Juan, Wang Jin-Xing. 2006, Identification of Differentially Expressed Proteins during Larval Molting of Helicoverpa armigera. Journal of Proteome Research. Jan. 5:164-169.

29Zhao Xiao-Fan*,An Xiao-Meng, Wang Jin-Xing, Dong Du-Juan, Du Xin-Jun, Sueda S. and Kondo H., 2005Expression of Helicoverpa cathepsin B-like proteinase during embryonic development. Archives of Insect Biochemistry and Physiology. Jan; 58: 39-46.

28Zhao Xiao-Fan*, Wang Jin-Xing, Li Fei-Xue, Sueda Shinji, Kondo Hiroki. 2005Analysis of substrate specificity and endopeptidyl cleavage sites of the cathepsin B-like proteinase from Helicoverpa armigera, The Protein Journal. May; 24:219 – 225.

27Zhao Xiao-fan*, Wang Jin-Xing, Xu Xia-Lian, Li Zhao-Min, Kang Cui-Jie, 2004Molecular cloning and expression patterns of molt-regulating transcription factor-hhr3 from Helicoverpa armigera. Insect Molecular Biology. Aug;13:407-412.

26.Zhao Xiaofan*, Li Zhaomin, Wang Jinxing, Wang Jiabao, Wang Shengli, Blankespoor D. Harvey, 2003, Efficacy of RH-2485, a new non-steroidal ecdysone agonist, against cotton bollworm, Helicoverpa armigera (lepidoptera: noctuidae) in laboratory and field. Crop Protection. Mar. 22959-965.

25.Zhao X-F*, Wang J-X, Xu X-L, Schmid R., Wieczorek H., 2002Molecular cloning and characterization of the cathepsin B-like proteinase from the cotton boll worm, Helicoverpa armigera. Insect Molecular Biology. Dec;11: 567-575.

24. Merzendorfer H.Reineke S.Zhao X-F, Jacobmeier B., Harvey W.R., Wieczorek H., 2000The multigene family of the tobacco hornworm V-ATPase: novel subunits a, C, D, H, and putative isoforms. Biochemica et Biophysica Acta. 1467:369-379.

23Zhao Xiao-Fan*, Wang Jin-Xing, Wang Yin-Chang1998, Purification and characterization of a cysteine proteinase from eggs of the cotton boll worm, Helicoverpa armigera. Insect Biochemistry and Molecular Biology. Aug; 28:259-264.

22.Zhao Xiaofan, Wang Jinxing, Noriko Yagi., Yamamoto Yoshimi, Watabe Shoji, Takahashi Y. Sussum, 1996Occurrence of a cathepsin B-like acid cystein proteinase in the eggs of silkworm moth, Antheraea pernyi. Comparative Biochemistry and Physiology. Jun; 113B: 95-103.

21. Takahashi S.Y., Yamamoto Y.,Zhao X-F, Watabe S., 1996, Bombyx acid cysteine proteinase. Invertebrate Reproduction and Development. 30:265-281.

20. Yamamoto Y.,Zhao X-FSuzuki A.C., Takahashi. S Y., 1994, Cysteine proteinase from the eggs of the Silkworm, Bombyx mori: site of synthesis and a suggested role in yolk protein degradation. Journal of Insect Physiology. 40: 447-454.

19. Takahashi S.Y.Zhao X-F Kageyama T., Yamamoto Y., 1992Acid cysteine proteinase from the eggs of silkmoth, Bombyx mori: tissue distribution, developmental changes and the sites of synthesis for the enzyme. Insect Biochemistry and Molecular Biology. 22: 369-377.

18.赵小凡2007,昆虫蜕皮的分子机理及应用。昆虫知识44323-326

17. 郑薇薇, 张玉宝, 王金星,赵小凡*2007,棉铃虫蜕皮时期同工酶表达模式。昆虫学报 50317-322

16.董杜鹃 扈进冬 张新昌 李子劲 王金星赵小凡*2006, HCBPichia中的表达及鉴定。生物工程杂志 26 : 44-48

15赵小凡基因组时代的昆虫学2005326-27

14. 张新昌,刘杨,王金星,赵小凡*, 2005,从大豆中纯化棉铃虫组织蛋白酶B抑制因子HCB-SoyI昆虫学报 48849-853

13.杨晓梅,侯立静,董杜鹃,王金星,赵小凡*2005, 组织蛋白酶B在棉铃虫发育过程中的表达及活性研究。山东大学学报. 40119-124

12.邵红莲,赵小凡*,董杜鹃,扈进冬,邵丁丁,杨晓梅,王金星,2005,棉铃虫组织蛋白酶B在杆状病毒表达系统中的表达。山东大学学报 40107-111

11、杨晓梅,侯立静,康翠洁,邵红莲,张新昌,杜欣军,王金星,赵小凡*, 2004,棉铃虫组织蛋白酶B单克隆抗体的制备及鉴定。山东大学学报39116-120

10.安晓萌,杜欣军,邵红莲,邵丁丁,赵小凡*,王金星,2004, 棉铃虫组织蛋白酶B多克隆抗体制备及鉴定。昆虫知识 41:132-126

9.杜欣军,邵丁丁,赵小凡*,王金星,2004, 棉铃虫组织蛋白酶B在大肠杆菌中的表达。农业生物技术学报 12162-166

8赵小凡*,蒋晓娟,杜欣军,徐筠娉,王金星,2004,棉铃虫蜕皮调节转录因子在大肠杆菌中的重组表达及包涵体纯化。昆虫学报, 47281-286

7. 李照民,赵小凡*,王金星,李斐雪,王家宝,王胜利, 2003,非甾醇类蜕皮激素竞争物RH-2485对棉铃虫蛋白质组成和表皮结构的影响。动物学研究, 24140-143

6. 张志宏,赵小凡*, 王金星, 2002,棉铃虫卵内半胱氨酸蛋白酶的分离纯化、氨基酸序列分析及蛋白酶鉴定。昆虫学报45840-843

5. 张志宏, 王金星,赵小凡*, 王来元,2002 棉铃虫雌性成虫脂肪体cDNA文库的构建。山东大学学报 37449-451

4. 李照民,赵小凡*, 李斐雪,王金星,2002RH-2485对棉铃虫实验室防治效果实验。植物保护学报 2978-82

3. 徐夏莲,赵小凡*, 王金星,2001,棉铃虫组织蛋白酶B组织分布与合成部位研究。动物学研究22242-245

2. 李斐雪, 李照民, 张志宏, 徐夏莲,赵小凡*, 王金星, 2001,棉铃虫半胱氨酸蛋白酶底物特异性研究。农业生物技术学报9152-155

1.赵小凡, 2001, 昆虫学研究热点述评。《国际学术动态》251-53

 

 

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